HIV Super Infection Study (HISIS)

 

Decription

basing on samples obtained from 600 prostitutes in during the HISIS study, correlates of protective immunity are evaluated. In a case-control-study, cellular immunity is examined using ELISPOT and intracellular cytokine staining (ICC) in three subgroups:
Women massively exposed to HIV during three years as prostitutes, who are HIV-negative;
Women infected with HIV once, whose immune response is preventing superinfection with another HIV strain;
Women whose immune response is insufficient to prevent infection, resulting in several infections with HIV.
Thus, correlates of protective immunity shall be identified. First results how certain HLA alleles (B5801, B8101, B0702) to induce a borader immunity in gag, which contributes to a long-term reduction in viral load by two log steps.

LMU Department of Infectious Diseases and Tropical Medicine is participating in this activity through its immunologists L. Podola, PhD and C. Geldmacher, PhD, who are planning and analysing this study together with colleagues in the NIMR-MMRC immunology laboratory.

Project Coordinator: L. Maboko

You can reach us at:

NIMR - Mbeya Medical Research Center
P.O Box 2410
Hospital Hill rd, Mbeya Tanzania

Tel +255 25 250 3364
Fax +255 25 250 3134

Working hours:
Mon - Fri
08:00 - 17:00 EAT (GMT + 3)

Or send us an email at This email address is being protected from spambots. You need JavaScript enabled to view it.

Our Twitter Feed

NIMRMbeya RT @TBtrials_StAnd: “We MUST run faster than the diseases through prevention & management factoring multidisciplinary approaches collaborat…
24mreplyretweetfavorite
NIMRMbeya Deputy Minister MoHCDGEC Dr. Faustine Ndugulile (sitted at the center) in a group photo with members of the Execu… https://t.co/g6GVYT9mu3
9hreplyretweetfavorite
NIMRMbeya Deputy Minister MoHCDGEC Dr. Faustine Ndugulile giving a commencement speech for the annual PanACEA Consortium mee… https://t.co/p3XGG56KBd
10hreplyretweetfavorite
NIMRMbeya RT @PanACEA_II: The 10th PanACEA Annual Meeting in Mbeya, TZ is officially opened by centre director Dr Ntingya, council chair Dr Mtasiwa,…
10hreplyretweetfavorite
NIMRMbeya RT @SabiitiwWilber: The PanACEA 10th forum opens with exciting opening remarks from Dr Ntinginya, Prof Bouree, Prof Mgaya-NIMR director, NI…
10hreplyretweetfavorite
© 2017 NIMR - Mbeya Medical Research Center