NIMR - Mbeya Medical Research Programme

Quick Information

NIMR - Mbeya Medical
Research Center

P.O Box 2410
Hospital Hill rd, Mbeya Tanzania

Tel    +255 25 250 3364
Fax   +255 25 250 3134
Working hours:
Mon   -  Fri
08:00 - 16:30 EAT (GMT + 3)

MMRC Publications

1. Hoelscher M; Riedner G; Hemed Y; Wagner HU; Korte R; Von Sonnenburg F: Estimating the number of HIV transmissions through reused syringes and needles in the Mbeya Region, Tanzania. AIDS. 8/11 (1609-1615) 1994
2. Korber B and Hoelscher M: HIV-1 subtypes: Implications for epidemiology, pathogenicity, vaccines and diagnostics. AIDS. 11/15 (17-36) 1997
3. Hoelscher M; Hanker S; Barin F; Cheingsong-Popov R; Dietrich U; Jordan Harder B; Olaleye D; Nagele E; Markuzzi A; Mwakagile D; Minja F; Weber J; Gürtler L; Von Sonnenburg F: HIV type 1 V3 serotyping of Tanzanian samples: Probable reasons for mismatching with genetic subtyping. AIDS Res Hum Retroviruses 1998; 14/2 (139-149)
4. Hoelscher M, Kim B, Maboko L, Mhalu F, von Sonnenburg F, Birx DL, McCutchan FE: High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania. AIDS. 2001 Aug 17;15(12):1461-1470 
5. Hoelscher M, Sanders-Buell E, Dowling W, Carr JK, Harris M, Thomschke A, Robb M, Birx DL, and McCutchan FE: Detection of HIV-1 subtypes, recombinants, and dual infections in east Africa by a multi-region hybridization assay. AIDS. 2002 Oct 18; 16(15):2055-64. 
6. Riedner G, Grosskurth H, Rusizoka M, Mwakyelu J, Nichombe F, Lyamuya E, Hoffmann O, Maboko L, Mmbando D, Todd J, Mabey D, Hoelscher M, Hayes R. Sexually transmitted infections and HIV in a cohort of female bar-workers in Mbeya region, Tanzania. Sex Transm Infect. 2003 Oct;79(5):382-7 
7. Arroyo M, Hoelscher M, Sanders-Buell E, Herbinger KH, Samky E, Maboko L, Hoffmann O, Robb M, Birx M, McCutchan F. HIV-1 Subtypes Among Blood Donors in the Mbeya Region of Southwest Tanzania. AIDS Res Hum Retroviruses. 2004 Aug;20(8):895-901
8. Hoffmann O, Zaba B, Wolff B, Sanga E, Maboko L, Mmbando D, von Sonnenburg F, Hoelscher M. Methodological lessons from a cohort study of high risk women in Tanzania. Sex Transm Infect 2004;80(Suppl II):ii69–ii73 
9. Gerhardt M, Mloka D, Tovanabutra S, Sanders-Buell E, Hoffmann O, Maboko L, Mmbando D, Birx DL, McCutchan FE, Hoelscher M. In-depth, longitudinal analysis of the viral quasispecies in a late-staged HIV-1 triple infected individual using a multiple PCR primer approach. J Virol. 2005 Jul;79(13):8249-61 
10. Boehme C, Molokova E, Minja F, Geis S, Loscher T, Maboko L, Koulchin V and Hoelscher M. Detection of mycobacterial lipoarabinomannan with an antigen-capture ELISA in unprocessed urine of Tanzanian patients with suspected tuberculosis. Trans R Soc Trop Med Hyg. 2005 Aug 30 
11. McCutchan FE, Hoelscher M, Tovanabutra S, Piyasirisilp S, Sanders-Buell E, Ramos G, Jagodzinski L, Polonis V, Maboko L, Mmbando D, Hoffmann O, Riedner G, von Sonnenburg F, Robb M, and Birx DL. First In-Depth Analysis of a Heterosexually Acquired HIV-1 Superinfection: Evolution, Temporal Fluctuation, and Inter-Compartment Dynamics from the Seronegative Window Period Through 30 Months Post-Infection. J. Virol. 2005 79: 11693-11704.
12. Arroyo M, Hoelscher M, Sateren W, Schoen G, Samky E, Maboko L, Hoffmann O, Sanders-Buell E, Kijak G, Robb M, Birx D and McCutchan F. HIV-1 Diversity and Prevalence Differ between Urban and Rural Areas in Mbeya Region, Tanzania. AIDS. 2005 Sep 23;19(14):1517-1524
13. Riedner G, Rusizoka M, Todd J, Hoelscher M, Maboko L, Mmbando D, Samky E, Lyamuya E, Mabey D, Grosskurth H, Hayes R: High efficacy of single dose treatment of early syphilis with 2g azithromycin in a randomised controlled trial. N Engl J Med. 2005 Sep 22;353(12):1236-44 
14. Riedner G, Hoffmann O, Rusizoka M, Lyamuya E, Mmbando D, Maboko L, Nichombe F, Dechamps B, McCutchan F, Zaba B, Grosskurth H, Todd J, Hayes R, Hoelscher M. Decline in STI prevalence and HIV incidence in female barworkers attending HIV/STI prevention and care services in Mbeya Region, Tanzania. In press AIDS 2006
15. Herbinger KH, Gerhardt M, Piyasirisilp S, Mloka D, Arroyo M, Hoffmann O, Maboko L, Birx D, Mmbando D, McCutchan F and Hoelscher M. Frequency of HIV-1 multiple infection and HIV diversity: analysis of low and high risk populations in Mbeya region, Tanzania. In press AIDS Res Hum Retroviruses 2006

16. CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients. Geldmacher et al. J Virol. 2007 Mar; 81(5):2440-8.

17. Minor viral and host genetic polymorphisms can dramatically impact the biological outcome of an epitope-specific CD8 T cell response. Geldmacher et al. Blood 2009 Aug 20;114(8):1553-62.

18. Early Depletion of Mycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV-1 Infection. Geldmacher et al. J Infect Dis. 2008 Dec 1;198(11):1590-8

19. In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype. Geldmacher et al. AIDS 2007 Jan 11; 21(2):135-43.

20 A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection. Geldmacher et al. J Virol. 2007 Dec; 81(24):13809-15.