NIMR - Mbeya Medical Research Programme

Quick Information

NIMR - Mbeya Medical
Research Center

P.O Box 2410
Hospital Hill rd, Mbeya Tanzania

Tel    +255 25 250 3364
Fax   +255 25 250 3134
Working hours:
Mon   -  Fri
08:00 - 16:30 EAT (GMT + 3)

Immunology Lab Publications

Monitoring CD27 expression to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo

Schuetz A, Haule A, Reither K, Ngwenyama N, Rachow A, Meyerhans A, Maboko L, Koup RA, Hoelscher M and Geldmacher C

PLOS one, in press September 2011

Pathogen-specific CD4 T cell loss during HIV infection: Impact of T cell phenotype and function.

Geldmacher C and Koup RA

Submitted to Trends in Immunology, Nov. 2011


Pathogen-prevalence may determine maintenance of antigen-specific T-cell responses in HIV-infected individuals

Alexandra SCHUETZ2,3,4*, Jan DIRKS1*, Urban SESTER3, Antelmo HAULE4, Nyanda ELIAS4, Christof GELDMACHER4,5, Erica SANGA4, Leonard MABOKO4, Klaus REITHER5, Michael HOELSCHER5, Andreas MEYERHANS2,6, and Martina SESTER1

Submitted to AIDS Oct., 2011


Preferential infection and depletion of Mycobacterium tuberculosis (MTB)-specific CD4 T cells after HIV-1 infection

Geldmacher C*, Ngwenyama N*, Schuetz A, Petrovas C, Reither K, Heeregrave EJ, Casazza J, Ambrozak D, Louder M, Ampofo W, Pollakis G, Hill B, Sanga E, Saathoff E, Maboko L, Roederer M, Paxton WA, Hoelscher M and Koup RA

J Exp Med. 2010 Dec 20;207(13):2869-81                                                              

* Geldmacher & Ngwenyama are Co-first authors


A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost  vaccine in HIV-Uninfected East Africans (RV 172).

Kibuuka H, Kimutai R, Maboko L, Sawe F, Schunk MS, Kroidl A, Shaffer D, Eller LA, Kibaya R, Eller MA, Schindler KB, Schuetz A, Millard M, Kroll J, Dally L, Hoelscher M, Bailer R, Cox JH, Marovich M, Birx DL, Graham BS, Michael NL, de Souza MS, Robb ML

J Infect Dis. 2010 Feb 15;201(4):600-7


Minor viral and host genetic polymorphisms can dramatically impact the biological outcome of an epitope-specific CD8 T cell response

Geldmacher C, Metzler IS, Tovanabutra S, Asher TE, Gostick E, Ambrozak DR, Petrovas C, Schuetz A, Ngwenyama N, Kijak G, Maboko L, Hoelscher M, McCutchan F, Price DA, Douek DC and Koup RA              

Blood. 2009 Aug 20;114(8):1553-62.                       


Reply to Robert Wallis: Significance of Early Secreted Antigenic Target 6–Specific T Cell Depletion after HIV-1 Infection

Geldmacher C, Heinrich N, Koup RA, Hoelscher M

Correspondence, J Infect Dis. 2009:200 (1 July)                          


Early Depletion of Mycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV-1 Infection

Geldmacher C, Schuetz A, Ngwenyama N, Casazza JP, Sanga E, Saathoff E,  Boehme C, Geis S, Maboko L, Singh M, Minja F, Meyerhans A, Koup RA, and Hoelscher M

J Infect Dis. 2008 Dec 1;198(11):1590-8                                                                 


A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection

Geldmacher C, Gray C, Nason M, Currier JR, Haule A, Njovu L, Geis S, Hoffmann O, Maboko L, Meyerhans A, Cox J, Hoelscher M

J Virol. 2007 Dec; 81(24):13809-15.                                                                                                

CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients

Geldmacher C, Currier JR, Herrmann E, Haule A, Kuta E, McCutchan F, Njovu L, Geis S, Hoffmann O, Maboko L, Williamson C, Birx D, Meyerhans A, Cox J, Hoelscher M

J Virol. 2007 Mar; 81(5):2440-8.                                                                                                                                         


In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype

Geldmacher C, Currier JR, Gerhardt M, Haule A, Maboko L, Birx D, Gray C, Meyerhans A, Cox J, Hoelscher M

AIDS. 2007 Jan 11; 21(2):135-43.