Immunology Lab Publications

Monitoring CD27 to evaluate Mycobacterium tuberculosis activity in HIV-1 infected individuals in vivo

Schurtz A, Haule A, Reither K, Ngwenyama N, Rachow A, Meyerhans A, Maboko L, Koup RA, Hoelscher M and Geldmacher C

PLOS one, in press September 2011

 

Pathogen-specific CD4 T cell loss during HIV infection: Impact of T cell phenotype and function.
Geldmacher C and Koup RA
Submitted to Trends in Immunology, Nov. 2011

 

Pathogen-prevalence may determine maintenance of antigen-specific T-cell responses in HIV-infected individuals
Alexandra SCHUETZ2,3,4*, Jan DIRKS1*, Urban SESTER3, Antelmo HAULE4, Nyanda ELIAS4, Christof GELDMACHER4,5, Erica SANGA4, Leonard MABOKO4, Klaus REITHER5, Michael HOELSCHER5, Andreas MEYERHANS2,6, and Martina SESTER1
Submitted to AIDS Oct., 2011

 

Preferential infection and depletion of Mycobacterium tuberculosis (MTB)-specific CD4 T cells after HIV-1 infection
Geldmacher C*, Ngwenyama N*, Schuetz A, Petrovas C, Reither K, Heeregrave EJ, Casazza J, Ambrozak D, Louder M, Ampofo W, Pollakis G, Hill B, Sanga E, Saathoff E, Maboko L, Roederer M, Paxton WA, Hoelscher M and Koup RA
J Exp Med. 2010 Dec 20;207(13):2869-81

* Geldmacher & Ngwenyama are Co-first authors

 

A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost  vaccine in HIV-Uninfected East Africans (RV 172).
Kibuuka H, Kimutai R, Maboko L, Sawe F, Schunk MS, Kroidl A, Shaffer D, Eller LA, Kibaya R, Eller MA, Schindler KB, Schuetz A, Millard M, Kroll J, Dally L, Hoelscher M, Bailer R, Cox JH, Marovich M, Birx DL, Graham BS, Michael NL, de Souza MS, Robb ML
J Infect Dis. 2010 Feb 15;201(4):600-7

 
Minor viral and host genetic polymorphisms can dramatically impact the biological outcome of an epitope-specific CD8 T cell response
Geldmacher C, Metzler IS, Tovanabutra S, Asher TE, Gostick E, Ambrozak DR, Petrovas C, Schuetz A, Ngwenyama N, Kijak G, Maboko L, Hoelscher M, McCutchan F, Price DA, Douek DC and Koup RA             
Blood. 2009 Aug 20;114(8):1553-62.

 

Reply to Robert Wallis: Significance of Early Secreted Antigenic Target 6–Specific T Cell Depletion after HIV-1 Infection
Geldmacher C, Heinrich N, Koup RA, Hoelscher M
Correspondence, J Infect Dis. 2009:200 (1 July)                         

 
Early Depletion of Mycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV-1 Infection
Geldmacher C, Schuetz A, Ngwenyama N, Casazza JP, Sanga E, Saathoff E,  Boehme C, Geis S, Maboko L, Singh M, Minja F, Meyerhans A, Koup RA, and Hoelscher M
J Infect Dis. 2008 Dec 1;198(11):1590-8                                                                

 
A high viral burden predicts the loss of CD8 T-cell responses specific for subdominant gag epitopes during chronic human immunodeficiency virus infection

Geldmacher C, Gray C, Nason M, Currier JR, Haule A, Njovu L, Geis S, Hoffmann O, Maboko L, Meyerhans A, Cox J, Hoelscher M
J Virol. 2007
Dec; 81(24):13809-15. 

                                                                                              

CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients
Geldmacher C, Currier JR, Herrmann E, Haule A, Kuta E, McCutchan F, Njovu L, Geis S, Hoffmann O, Maboko L, Williamson C, Birx D, Meyerhans A, Cox J, Hoelscher M
J Virol. 2007
Mar; 81(5):2440-8.

 

In a mixed subtype epidemic, the HIV-1 Gag-specific T-cell response is biased towards the infecting subtype
Geldmacher C, Currier JR, Gerhardt M, Haule A, Maboko L, Birx D, Gray C, Meyerhans A, Cox J, Hoelscher M
AIDS. 2007 Jan 11; 21(2):135-43.          

                                                                                                                                                                                                  

You can reach us at:

NIMR - Mbeya Medical Research Center
P.O Box 2410
Hospital Hill rd, Mbeya Tanzania

Tel +255 25 250 3364
Fax +255 25 250 3134

Working hours:
Mon - Fri
08:00 - 17:00 EAT (GMT + 3)

Or send us an email at This email address is being protected from spambots. You need JavaScript enabled to view it.

Our Twitter Feed

NIMRMbeya RT @TBtrials_StAnd: “We MUST run faster than the diseases through prevention & management factoring multidisciplinary approaches collaborat…
49mreplyretweetfavorite
NIMRMbeya Deputy Minister MoHCDGEC Dr. Faustine Ndugulile (sitted at the center) in a group photo with members of the Execu… https://t.co/g6GVYT9mu3
10hreplyretweetfavorite
NIMRMbeya Deputy Minister MoHCDGEC Dr. Faustine Ndugulile giving a commencement speech for the annual PanACEA Consortium mee… https://t.co/p3XGG56KBd
10hreplyretweetfavorite
NIMRMbeya RT @PanACEA_II: The 10th PanACEA Annual Meeting in Mbeya, TZ is officially opened by centre director Dr Ntingya, council chair Dr Mtasiwa,…
10hreplyretweetfavorite
NIMRMbeya RT @SabiitiwWilber: The PanACEA 10th forum opens with exciting opening remarks from Dr Ntinginya, Prof Bouree, Prof Mgaya-NIMR director, NI…
10hreplyretweetfavorite
© 2017 NIMR - Mbeya Medical Research Center